The Dark Matter Project
The Center for Synthetic Regulatory Genomics at NYU Langone Health
Research Aims:
We are tasked with development of a revolutionary technology for making coordinated changes to gene loci, enabling broad investigation of the function of regulatory sequences and foster translational applications to biotechnology, personalized medicine and gene therapy. Specifically, we will:
Assemble hundreds >100 kb DNA constructs (assemblons) probing regulatory function at a selected set of loci
Deliver these assemblons at desired sites genome-wide
Analyze assemblon libraries for effects on gene expression and chromatin features
Model the effects of sequence variation on gene expression
Disseminate knowledge
